TREM2, a Protective Factor Against Alzheimer’s Disease1
Recent genetic studies have revealed a major role for microglia in the progression of alzheimer’s disease (AD). The loss of TREM2 function, which is a key receptor expressed by microglia in the brain, contributes to AD development. Therefore, boosting the function of TREM2 may be a useful therapeutic strategy to decrease the risk for late onset AD. It was found that a reduction in memory decline and shrinkage of the hippocampus in AD patients were associated with higher concentrations of TREM2. These findings indicate important implications for future clinical trials to target the innate immune response in AD.
References
1. Ewers M, et al. Sci Transl Med 2019;11:eaav6221.
