Prostate cancer (PCa) is one of the most common malignancies in men worldwide, with incidence projected to rise from 1.4 million in 2020 to 2.9 million by 2040 due to aging populations and increased life expectancy 1 . In Hong Kong, PCa was the ...

Prostate cancer (PCa) is a complex disease that affects millions of males, globally. It is the 3rd most common cancer in males and the 4th leading cause of male cancer-related deaths in Hong Kong1. The aetiology of PCa is believed to be related to s...

Tumour protein 53 (TP53) gene is located on the chromosome 17 that encodes for the p53 protein, which is a tumour suppressor protein with 393 amino acid responsible for regulating cellular stress 1 . Notably, TP53 can be inactivated directly due to ...