Vitamin D Supplementation Demonstrates Beneficial Clinical Outcomes on Patients with Coronary Artery Disease¹

Despite the improvement in pharmacological treatments, coronary heart disease (CAD) remains one of the leading causes of morbidity and mortality worldwide. Vitamin D deficiency has also been regarded as one of the risk factors contributing to CAD recently. The underlying mechanisms are proposed to include the raised renin and angiotensin II levels, calcification and smooth muscle proliferation, followed by the raised lipid profile and featured metabolic syndrome. To assess the impact of vitamin D supplementation on clinical outcomes of patients with CAD, a pooled meta-analysis was conducted. Based on the four randomised clinical trials with a pool of 307 patients between 8 weeks to 6 months interventions, vitamin D supplementation in vitamin D deficient patients demonstrated favourable effects on diastolic blood pressure levels and parathyroid hormone concentrations. With such improvements in several cardiac outcomes, considering supplementing vitamin D in CAD patients with vitamin D deficiency as an adjunct therapy to routine treatment is recommended.

References

1. Bahrami LS, et al. Sci Rep 10. 2020;12923.