Receptor Protein in Brain Promotes Stress Resilience¹

Psychiatric disorders can develop due to stress and it has been shown that the sphingosine-1-phosphate receptor 3 (S1PR3) in the medial prefrontal cortex (mPFC) of rats regulate resilience to chronic social defeat stress. It was suggested that the increase in S1PR3 in mPFC occurred as a function of stress experience and was not pre-existing. The PTSD symptom severity was inversely correlated with the S1PR3 mRNA levels and revealed that blood S1PR3 mRNA was reduced in PTSD patients compared to veterans without PTSD. It was ultimately discussed that sphingolipid receptors are important substrates of relevance to any stress-related psychiatric disorders.

References

1. Corbett BF, et al. Nat Commun 2019;10:3146.