Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as the most prevalent liver disorder globally, affecting 20-30% of the general population. NAFLD manifests as a wide range of hepatic damage with varying severity ranging from simple steatosis to a more severe Non-Alcoholic Steatohepatitis (NASH), with or without fibrosis, cirrhosis, and potentially hepatocellular carcinoma. A recent systematic review indicated that vitamin deficiency has been associated with NAFLD development and increased susceptibility to more severe liver damage. Essentially, derangement in vitamins correlates to the lipotoxic hepatic environment, altered immune system, unwarranted inflammation, oxidative stress, gene mutations, epigenetic modification, and gut dysbiosis seen in NAFLD. Notably, vitamins A, B3, B6, B9, B12, C, D, and E are suggested to be potential options that can impact NAFLD management.