The association of habitual coffee consumption with a lower risk of diseases such as type 2 diabetes mellitus and certain cancer types has been reported in prospective cohort studies. Nonetheless, the molecular mechanism is still unresolved. In a recent clinical study, a higher level of Bacteroides-Prevotella-Porphyromonas and lower levels of lipoperoxidation were shown to be associated with high-coffee consumption (45-500 mL/day). Of note, two groups of coffee-derived (poly)phenol  (methoxyphenols and alkylphenols) and caffeine, among alkaloids, were directly associated with Bacteroides group levels. Hence, regular consumption of coffee appears to be associated with changes in some gut microbiota groups, whereas modulation of the gut microbiota would possibly play a role in the risk reduction against certain non-transmissible pathologies upon coffee consumption.

Keyword: Coffee, gut microbiota, Disease prevention

Reference

González et al., Nutrients. 2020;12(5):1287.