Psoriasis is a chronic immune-mediated disease of the skin, with wide dermatological manifestations, most commonly involving erythematous, scaly plaques on the extensor surfaces of the joints, whereas psoriatic arthritis is also a common coexisting condition.  Cardiorespiratory fitness is the overall capacity to perform exertion exercise and low levels of cardiorespiratory fitness are associated with negative health outcomes. To investigate whether low cardiorespiratory fitness increases the risk for onset of psoriasis and psoriatic arthritis, a prospective cohort study was conducted and found that low cardiorespiratory fitness at an early age was associated with increased risk of incident psoriasis and psoriatic arthritis among men. The findings highlight the importance of assessing cardiorespiratory fitness early in life.