Obesity is a threatening public health issue with severe health consequences. Apart from pharmacological and dietary interventions, natural supplements like grape seed extract (GSE) are also beneficial. Rich in polyphenols with strong antioxidant and anti-inflammatory properties, GSE is proposed to help reduce obesity-related inflammation and control body weight by preventing lipid peroxidation and suppressing the production of pro-inflammatory cytokines. In agreement with the proposed mechanisms of GSE, a recent clinical trial demonstrated that a 12-week GSE supplementation in addition to dietary intervention significantly reduced body weight, body mass index, waist circumference, waist-to-hip ratio and inflammatory mediators including tumour necrosis factor α and high‐sensitivity C‐reactive protein in obese individuals compared to the placebo group. Therefore, GSE may be considered as a healthy supplement to fight against obesity.

Keywords: grape seed extract, obesity, polyphenols, inflammation

Reference

Parandoosh M et al. Phyther Res. 2020;34:379-387.